产品名称

pro Caspase 3 Antibody

产品货号

AF300110

基因名称

pro Caspase 3

蛋白名称

pro Caspase 3

其他名称

CASP3; Caspase-3; APOPAIN; CPP32; CPP32B; SCA-1;

SwissPro

Human:P42574    

宿主种属

Rabbit

应用范围

WB IHC ICC/IF IP FC

稀释比例

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

反应种属

Human Mouse

克隆性

Monoclonal

免疫原

A synthesized peptide derived from human pro Caspase 3

特异性

pro Caspase 3 Antibody detects endogenous levels of total pro Caspase 3

同种型

Rabbit IgG

保存液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式

Affinity-chromatography

保存条件

-20°C/1 year

背景资料

35kDa

产品概述

Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins such as the nuclear enzyme poly(ADP-ribose) polymerase (PARP). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires aspartic acid at the P1 position.