产品名称

Bax Antibody

产品货号

AF300120

基因名称

Bax

蛋白名称

Bax

其他名称

Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4

SwissPro

Human:Q07812    

宿主种属

Rabbit

应用范围

WB IHC IP FC

稀释比例

WB 1:1000~1:2000 IHC 1:50~1:200 IP 1:50 FC 1:50

反应种属

Human Mouse Rat Hamster

克隆性

Monoclonal

免疫原

A synthesized peptide derived from human Bax

特异性

Bax Antibody detects endogenous levels of total Bax

同种型

Rabbit IgG

保存液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式

Affinity-chromatography

保存条件

-20°C/1 year

背景资料

21kDa

产品概述

Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.