产品名称

p21 Antibody

产品货号

AF300146

基因名称

p21

蛋白名称

p21

其他名称

CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; P21cip1;

SwissPro

Human:P38936    

宿主种属

Rabbit

应用范围

WB IHC ICC/IF IP

稀释比例

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

反应种属

Human

克隆性

Monoclonal

免疫原

A synthesized peptide derived from human p21

特异性

p21 Antibody detects endogenous levels of total p21

同种型

Rabbit IgG

保存液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式

Affinity-chromatography

保存条件

-20°C/1 year

背景资料

21kDa

产品概述

The tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S. However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D.