产品名称

Torsin A Antibody

产品货号

AF300231

基因名称

Torsin A

蛋白名称

Torsin A

其他名称

TOR1A;DQ2; DYT1; TorsinA;

SwissPro

Human:O14656    

宿主种属

Rabbit

应用范围

WB FC

稀释比例

WB 1:500~1:2000 FC 1:50

反应种属

Human

克隆性

Monoclonal

免疫原

A synthesized peptide derived from human Torsin A

特异性

Torsin A Antibody detects endogenous levels of total Torsin A

同种型

Rabbit IgG

保存液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式

Affinity-chromatography

保存条件

-20°C/1 year

背景资料

35kDa

产品概述

The neurological condition Dystonia is associated with sustained muscle contractions and abnormal posturing. TorsinA, torsinB, torp2A and torp3A belong to the family of ATPases associated with cellular activites (AAA+) and mutations in torsinA cause early onset dystonia. TorsinA has been shown to suppress intracellular protein aggregation in C. elegans and possesses chaperon activity. Interestingly, torsinA is highly expressed in dopaminergic neurons and associates with alpha-synuclein in Lewy b