产品名称

LRRK2 Antibody

产品货号

AF300240

基因名称

LRRK2

蛋白名称

LRRK2

其他名称

Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; PARK8; ROCO2; RIPK7; LRRK2

SwissPro

Human:Q5S007    

宿主种属

Rabbit

应用范围

WB IHC ICC/IF

稀释比例

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

反应种属

Human Mouse

克隆性

Monoclonal

免疫原

A synthesized peptide derived from human LRRK2

特异性

LRRK2 Antibody detects endogenous levels of total LRRK2

同种型

Rabbit IgG

保存液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式

Affinity-chromatography

保存条件

-20°C/1 year

背景资料

286kDa

产品概述

LRRK2 positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.